Hydrochloric Acid → 1-(Benzyloxycarbonylamino)-2-phenylethyl-phosphonic acid

Participants

Reaction Steps

To a solution of 1-benzyloxycarbonylamino2-phenylethyl phosphonous acid (0.5 g, 0.0016 mole) in acetone (20 ml) and water (10 ml) was added a 10% solution of sodium hydroxide in water until a pH of about 7 was reached. A solution of KMnO4 (0.14 g, 0.00086 mole, 0.55 equiv.) in water (10 ml) was added slowly to the vigorously stirred solution of phosphonous acid at 20-25° C. After the addition (5 minutes), the reaction mixture was stirred for 5 minutes at ambient temperature and acidified with concentrated HCl acid until a pH of 1 was reached. Saturated sodium bisulfite solution was added to the reaction mixture thereby resulting in formation of a white precipitate.

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