Hydrochloric Acid → 1-(Benzyloxycarbonylamino)-2-phenylethyl-phosphonic acid

HRID 651936Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 651936
[CH2:1]([O:8][C:9]([NH:11][CH:12]([P:20]([OH:22])[OH:21])[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].[O-:25][Mn](=O)(=O)=O.[K+].P(O)O.Cl.S(=O)(O)[O-].[Na+]>CC(C)=O.O>[CH2:1]([O:8][C:9]([NH:11][CH:12]([P:20](=[O:25])([OH:21])[OH:22])[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

9

Edukt 6

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 516875Potassium PermanganateHCID 3014827Phosphonous acidHCID 145513411-Benzyloxycarbonylamino-2-phenylethylphosphonous acidHCID 23665763Sodium Bisulfite

Produkt 1

HCID 109805691-(Benzyloxycarbonylamino)-2-phenylethyl-phosphonic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 180AcetoneLösungsmittelHCID 962WaterLösungsmittel3×

Versuchsvorschrift

To a solution of 1-benzyloxycarbonylamino2-phenylethyl phosphonous acid (0.5 g, 0.0016 mole) in acetone (20 ml) and water (10 ml) was added a 10% solution of sodium hydroxide in water until a pH of about 7 was reached. A solution of KMnO4 (0.14 g, 0.00086 mole, 0.55 equiv.) in water (10 ml) was added slowly to the vigorously stirred solution of phosphonous acid at 20-25° C. After the addition (5 minutes), the reaction mixture was stirred for 5 minutes at ambient temperature and acidified with concentrated HCl acid until a pH of 1 was reached. Saturated sodium bisulfite solution was added to the reaction mixture thereby resulting in formation of a white precipitate.

Aufarbeitung

  1. additionAfter the addition (5 minutes)
  2. customthereby resulting in formation of a white precipitate

Quellen und Nachweise

ORD-Eintrag
ord-da1de098c3ae402db57b5e38d1d3a25a
Quelldatensatz
uspto-grants-1987_06
Patentnummer
US04670193

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