反应详情

To an ice-cooled suspension of 1.0 gram of N2 -dansyl-L-arginine in 15 ml of isopropanol was added dropwise 0.5 ml of thionyl chloride with vigorous stirring. After being allowed to stand for 2 hours at room temperature, the reaction mixture was refluxed for 4 hours, and was evaporated to dryness (syrup). Treatment of the residual syrup with cold ethyl ether gave crude crystals. After recrystallization from isopropanol-ethyl ether, colorless N2 -dansyl-L-arginine isopropyl ester dihydrochloride was obtained in 90% yield; mp. 110°-120° C.

1. temperaturethe reaction mixture was refluxed for 4 hours
2. customwas evaporated to dryness (syrup)
3. customTreatment of the residual syrup with cold ethyl ether gave crude crystals
4. customAfter recrystallization from isopropanol-ethyl ether