Ethylamine → HCID 178465191, compound

HRID 651982Notes

Reaction equation

HRID 651982 reaction equation
[N:1]#[N:2].O.Cl.Cl.C[O:7][C:8](=[O:34])[C@H:9]([CH2:27][CH2:28][CH2:29][NH:30][C:31](=[NH:33])[NH2:32])[NH:10][S:11]([C:14]1[C:26]2[CH:25]=[CH:24][CH:23]=[C:19]([N:20]([CH3:22])[CH3:21])[C:18]=2[CH:17]=[CH:16][CH:15]=1)(=[O:13])=[O:12].[CH2:35]([NH2:37])[CH3:36]>O1CCCC1>[N:1]#[N:2].[OH2:7].[S:11]([NH:10][C@H:9]([C:8]([NH:37][CH2:35][CH3:36])=[O:34])[CH2:27][CH2:28][CH2:29][NH:30][C:31](=[NH:33])[NH2:32])([C:14]1[C:26]2[CH:25]=[CH:24][CH:23]=[C:19]([N:20]([CH3:21])[CH3:22])[C:18]=2[CH:17]=[CH:16][CH:15]=1)(=[O:12])=[O:13]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 178501461HCID 178501461, compound

Product 1

HCID 178465191HCID 178465191, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a suspension of 1.0 gram of N2 -dansyl-L-arginine methyl ester dihydrochloride monohydrate in 1 ml of tetrahydrofuran was added 3 ml of ethylamine with cooling. The mixture was allowed to stand in a sealed tube at room temperature for three days. After the excess amine was removed by evaporation, the residue was poured into 50 ml of water to give a precipitate. Recrystallization from 50% aqueous methanol afforded N2 -dansyl-N-ethyl-L-argininamide monohydrate in 93% yield; mp. 220°-222° C.

Workup

  1. temperaturewith cooling
  2. customAfter the excess amine was removed by evaporation
  3. additionthe residue was poured into 50 ml of water
  4. customto give a precipitate
  5. customRecrystallization from 50% aqueous methanol

Sources & evidence

ORD record
ord-d346b8a15d624195bda3e3780fcce925
Source dataset
uspto-grants-1987_06
Patent number
US04670420

Reaction notes

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