HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-cyclohexyl-N-methyl-4-(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]-quinazolin-7-yl)oxybutanamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | N-cyclohexyl-N-methyl-4-(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)oxybutanamide | HCID 135626217 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-cyclohexyl-N-methyl-4-(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]-quinazolin-7-yl)oxybutanamide hydrochloride | HCID 135626310 | — |
Reaction Steps
A two-fold stoichiometric excess of 3% hydrogen chloride in methanol is added to a solution of 1.0 g. of N-cyclohexyl-N-methyl-4-(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolin-7-yl)oxybutanamide in 20 ml methanol. Diethyl ether is added until precipitation is complete. The product is filtered, washed with ether, air dried and recrystallized to give N-cyclohexyl-N-methyl-4-(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]-quinazolin-7-yl)oxybutanamide hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04670434 |
| Source dataset | uspto-grants-1987_06 |
| ORD ID | ord-79ac121b4b674987b841029290047032 |
| Source note | uspto-grants-1987_06 |