Hydrochloric Acid → N-cyclohexyl-N-methyl-4-(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]-quinazolin-7-yl)oxybutanamide hydrochloride

HRID 652001Notes

Reaction equation

HRID 652001 reaction equation
[ClH:1].[CH:2]1([N:8]([CH3:30])[C:9](=[O:29])[CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][CH:23]=2)[N:20]=[C:19]2[NH:24][C:25](=[O:28])[C:26](=[CH2:27])[N:18]2[CH2:17]3)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.C(OCC)C>CO>[ClH:1].[CH:2]1([N:8]([CH3:30])[C:9](=[O:29])[CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][CH:23]=2)[N:20]=[C:19]2[NH:24][C:25](=[O:28])[C:26](=[CH2:27])[N:18]2[CH2:17]3)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 135626217N-cyclohexyl-N-methyl-4-(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)oxybutanamide

Product 1

HCID 135626310N-cyclohexyl-N-methyl-4-(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]-quinazolin-7-yl)oxybutanamide hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A two-fold stoichiometric excess of 3% hydrogen chloride in methanol is added to a solution of 1.0 g. of N-cyclohexyl-N-methyl-4-(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolin-7-yl)oxybutanamide in 20 ml methanol. Diethyl ether is added until precipitation is complete. The product is filtered, washed with ether, air dried and recrystallized to give N-cyclohexyl-N-methyl-4-(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]-quinazolin-7-yl)oxybutanamide hydrochloride.

Workup

  1. filtrationThe product is filtered
  2. washwashed with ether, air
  3. customdried
  4. customrecrystallized

Sources & evidence

ORD record
ord-79ac121b4b674987b841029290047032
Source dataset
uspto-grants-1987_06
Patent number
US04670434

Reaction notes

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