反应详情

A two-fold stoichiometric excess of 3% hydrogen chloride in methanol is added to a solution of 1.0 g. of N-cyclohexyl-N-methyl-4-(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolin-7-yl)oxybutanamide in 20 ml methanol. Diethyl ether is added until precipitation is complete. The product is filtered, washed with ether, air dried and recrystallized to give N-cyclohexyl-N-methyl-4-(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]-quinazolin-7-yl)oxybutanamide hydrochloride.

1. filtrationThe product is filtered
2. washwashed with ether, air
3. customdried
4. customrecrystallized