HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 3-Hydroxypropyl 4-[14-(trimethylsilyl)tetradecylamino]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 1,3-Propanediol | HCID 10442 | — |
| Reactant | Methyl 4-[14-(trimethylsilyl)tetradecylamino]benzoate | HCID 20198250 | — |
| Product | 3-Hydroxypropyl 4-[14-(trimethylsilyl)tetradecylamino]benzoate | HCID 20198238 | — |
Reaction Steps
A mixture of 2.2 g. of methyl 4-[14-(trimethylsilyl)tetradecylamino]benzoate, 280 mg. of 1,3-propanediol and 1.37 g. of p-toluenesulfonic acid is heated at 180° C. for 18 hours and then is partitioned between ether and 3% aqueous sodium carbonate solution. The ether layer is separated, dried, and evaporated to yield the product as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04670421 |
| Source dataset | uspto-grants-1987_06 |
| ORD ID | ord-932668b7749347b1a028643aa6f6a0a1 |
| Source note | uspto-grants-1987_06 |