Amlodipine → HCID 178469320, compound

HRID 652067Notes

Reaction equation

HRID 652067 reaction equation
[NH2:1][CH2:2][CH2:3][O:4][CH2:5][C:6]1[NH:7][C:8]([CH3:28])=[C:9]([C:24]([O:26][CH3:27])=[O:25])[CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[Cl:23])[C:11]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13].[CH3:29][S:30][C:31](SC)=[N:32][C:33]#[N:34].CCOCC>C(O)(C)C>[Cl:23][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[CH:10]1[C:9]([C:24]([O:26][CH3:27])=[O:25])=[C:8]([CH3:28])[NH:7][C:6]([CH2:5][O:4][CH2:3][CH2:2][NH:1][C:31](=[N:32][C:33]#[N:34])[S:30][CH3:29])=[C:11]1[C:12]([O:14][CH2:15][CH3:16])=[O:13]

Participants

5

Reactant 3

HCID 2162AmlodipineHCID 3283Diethyl EtherHCID 66289Dimethyl N-cyanodithioiminocarbonate

Product 1

HCID 178469320HCID 178469320, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

2-[2-Aminoethoxymethyl]-3-ethoxycarbonyl-4-(2-chlorophenyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (4.3 g) and dimethyl N-cyanoimidodithiocarbonate (2 g) in isopropanol (15 ml) were allowed to stand at room temperature for 4 hours. Ether (30 ml) was then added and the mixture was stood at room temperature overnight. The crystalline precipitate was filtered, washed with ether and dried, yield of the title compound 5.0 g, m.p. 177°-179°.

Workup

  1. waitthe mixture was stood at room temperature overnight
  2. filtrationThe crystalline precipitate was filtered
  3. washwashed with ether
  4. customdried

Sources & evidence

ORD record
ord-4cb45c9c53d1479fb703e4aafe11404b
Source dataset
uspto-grants-1987_06
Patent number
US04670449

Reaction notes

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