Ethanol → Arachidonic Acid

HRID 652082Notes

Reaction equation

HRID 652082 reaction equation
[C:1]([OH:20])(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[CH2:21](O)[CH3:22]>>[C:1]([OH:20])(=[O:19])[CH2:2][CH2:3][CH2:4]/[CH:5]=[CH:6]\[CH2:7]/[CH:8]=[CH:9]\[CH2:10]/[CH:11]=[CH:12]\[CH2:13]/[CH:14]=[CH:15]\[CH2:16][CH2:17][CH2:18][CH2:21][CH3:22]

Participants

3

Reactant 2

HCID 702Ethanol4×HCID 445639Oleic Acid

Product 1

HCID 444899Arachidonic Acid

Procedure

Rats receiving intragastric pretreatment with PL solution only had 3 hours after ethanol macroscopic hemorrhagic lesions involving 35.8±2% of glandular mucosal area. Treatment with oleic acid did not change significantly occurrence of mucosal hemorrhagic lesions--29.1±3%. Rats receiving pretreatment with 120 mM and 240 mM LLC had significantly decreased macroscopic hemorrhagic lesions--6.5±1% and 1.3±0.5% respectively (p<0.01) 3 hours after ethanol. Macroscopic protection rat gastric mucosa against ethanol was similar to that afforded by arachidonic acid except for the presence of marked edema in the forestomach (containing squamous, paraepidermoidal epithelium) 3 hours after ethanol in group pretreated with linoleic acid (C).

Workup

  1. customwith PL solution only had 3 hours
  2. custommacroscopic hemorrhagic lesions--6.5±1% and 1.3±0.5% respectively (p<0.01) 3 hours

Sources & evidence

ORD record
ord-6cff0c288d0e46b69ea82a89a14613a4
Source dataset
uspto-grants-1987_06
Patent number
US04670468

Reaction notes

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