Trifluoroacetic acid → HCID 12774391, compound

HRID 652087Notes

Reaction equation

HRID 652087 reaction equation
S(O)(O)(=O)=O.[NH2:6][N:7]([CH3:11])[C:8]([NH2:10])=[NH:9].[F:12][C:13]([F:18])([F:17])[C:14](O)=O>>[CH3:11][N:7]1[C:8]([NH2:10])=[N:9][C:14]([C:13]([F:18])([F:17])[F:12])=[N:6]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 11956717AGN-PC-00IQ7S

Product 1

HCID 12774391HCID 12774391, compound

Procedure

1-Amino-1-methyl guanidine sulphate (12.3 g) and trifluoroacetic acid (16 ml) were heated at reflux for 96 h. Excess trifluoroacetic acid was removed by distillation and the residue was basified with sodium bicarbonate and extracted with ethyl acetate. The extract was dried and evaporated to give a white solid (7.2 g) which was recrystallised from a mixture of methyl acetate (8 ml) and petroleum ether (b.p. 60°-80°) (20 ml) to give the title compound as a white powder (5.1 g) m.p. 165°-166°.

Workup

  1. temperatureat reflux for 96 h
  2. customExcess trifluoroacetic acid was removed by distillation
  3. extractionextracted with ethyl acetate
  4. customThe extract was dried
  5. customevaporated

Sources & evidence

ORD record
ord-0e775d210eed495a89baa205f5aebe85
Source dataset
uspto-grants-1987_06
Patent number
US04670448

Reaction notes

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