Ammonia → 5-[4-[3-(1-Piperidinylmethyl)phenoxy]butyl]amino-1H-1,2,4-triazole-3-carboxamide

HRID 652095Notes

Reaction equation

HRID 652095 reaction equation
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:27]=[CH:28][CH:29]=2)[O:11][CH2:12][CH2:13][CH2:14][CH2:15][NH:16][C:17]2[NH:21][N:20]=[C:19]([C:22](OCC)=[O:23])[N:18]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH3:30]>>[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:27]=[CH:28][CH:29]=2)[O:11][CH2:12][CH2:13][CH2:14][CH2:15][NH:16][C:17]2[NH:21][N:20]=[C:19]([C:22]([NH2:30])=[O:23])[N:18]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 178470502HCID 178470502, compound

Product 1

HCID 1785138585-[4-[3-(1-Piperidinylmethyl)phenoxy]butyl]amino-1H-1,2,4-triazole-3-carboxamide

Procedure

A suspension of ethyl 5-[4-[3-(1-piperidinylmethyl)phenoxy]butyl]amino-1H-1,2,4-triazole-3-carboxylate (867 mg) in 0.88 ammonia (25 ml) was stirred at room temperature for 18 h. The mixture was evaporated and the residual solid was washed with boiling methanol to leave the title compound as a white solid (255 mg) m.p. 212°-4° dec.

Workup

  1. customThe mixture was evaporated
  2. washthe residual solid was washed with boiling methanol

Sources & evidence

ORD record
ord-14c83efbb5a6445a914eda5e07f698f2
Source dataset
uspto-grants-1987_06
Patent number
US04670448

Reaction notes

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