HCID 20199126, compound → HCID 178472251, compound

HRID 652107Notes

Reaction equation

HRID 652107 reaction equation
CN1C([NH:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)[CH:13]=2)=NC(CCC(O)=O)=N1.[CH3:30][N:31]([C:40](=[N:43][C:44](=[O:51])[CH2:45][C:46]([O:48][CH2:49][CH3:50])=[O:47])SC)[N:32]=[CH:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>>[CH3:30][N:31]([C:40](=[N:43][C:44](=[O:51])[CH2:45][C:46]([O:48][CH2:49][CH3:50])=[O:47])[NH:7][CH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH:13]=1)[N:32]=[CH:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1

Participants

3

Reactant 2

HCID 20199126HCID 20199126, compoundHCID 54510571HCID 54510571, compound

Product 1

HCID 178472251HCID 178472251, compoundYield 155.6%

Procedure

A mixture of 3-[3-(1-piperidinylmethyl)phenoxy]propanamine (A) (3.61 g) and ethyl 3-[[[1-methyl-2-(phenylmethylene)hydrazino](methylthio)methylene]amino]-3-oxopropanoate (4.7 g) was heated at 50° under water pump vacuum during 4 h. to gave the title compound as an orange gum (7.3 g). T.l.c. System D, Rf 0.65.

Workup

  1. temperaturewas heated at 50° under water pump vacuum during 4 h.

Sources & evidence

ORD record
ord-ddf84ac8e9ba4d7e84d51bdfb7ad6095
Source dataset
uspto-grants-1987_06
Patent number
US04670448

Reaction notes

Loading…