Thionyl Chloride → HCID 20199155, compound

HRID 652108Notes

Reaction equation

HRID 652108 reaction equation
[CH3:1][N:2]1[C:6]([NH:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19][N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH:14]=2)=[N:5][C:4]([CH2:26]O)=[N:3]1.S(Cl)([Cl:30])=O>>[Cl:30][CH2:26][C:4]1[N:5]=[C:6]([NH:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19][N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH:14]=2)[N:2]([CH3:1])[N:3]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 20199146HCID 20199146, compound

Product 1

HCID 20199155HCID 20199155, compound

Procedure

A mixture of 1-methyl-5-[4-[3-(1-piperidinylmethyl)phenoxy]butyl]amino-1H-1,2,4-triazole-3-methanol (0.75 g) and thionyl chloride (4 ml) was stirred at room temperature for 2 h. The mixture was evaporated in vacuo and the residue was dissolved in chloroform and washed with sodium bicarbonate. The organic extract was dried and evaporated to give the title compound as an oil (0.75 g) T.l.c. System E Rf 0.65.

Workup

  1. customThe mixture was evaporated in vacuo
  2. dissolutionthe residue was dissolved in chloroform
  3. washwashed with sodium bicarbonate
  4. extractionThe organic extract
  5. customwas dried
  6. customevaporated

Sources & evidence

ORD record
ord-553c893740a941f8ba4a8494e4e7ff58
Source dataset
uspto-grants-1987_06
Patent number
US04670448

Reaction notes

Loading…