Benzoyl chloride → HCID 14032620, compound

HRID 652148Notes

Reaction equation

HRID 652148 reaction equation
[CH3:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][CH:12]([C:15]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[NH:17][N:16]=2)[CH2:11][CH2:10]1.[C:24]([Cl:32])(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>CCOCC>[ClH:32].[C:24]([N:17]1[C:18]2[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:15]([CH:12]2[CH2:11][CH2:10][N:9]([CH2:4][CH2:5][C:6]3[CH:7]=[CH:8][CH:3]=[CH:2][CH:1]=3)[CH2:14][CH2:13]2)=[N:16]1)(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 178435995HCID 178435995, compound

Product 1

HCID 14032620HCID 14032620, compoundYield 51%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 1.6 g of 3-(1-pheneth-2-yl-4-piperidinyl)-1H-indazole and 7 ml of benzoyl chloride was heated at 100° for 2 hr. After cooling, ether was added and the solid was collected. The solid was combined with material from a prior experiment and recrystallized from methanol to yield 2.4 g (51%) of product, mp 248°-250° C.

Workup

  1. temperaturewas heated at 100° for 2 hr
  2. temperatureAfter cooling
  3. customthe solid was collected
  4. customrecrystallized from methanol

Sources & evidence

ORD record
ord-e9032a7800fe4848a1da2888e96a8934
Source dataset
uspto-grants-1987_06
Patent number
US04670447

Reaction notes

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