Benzoyl chloride, 3-chloro- → HCID 14032531, compound

HRID 652149Notes

Reaction equation

HRID 652149 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][N:9]=2)[CH2:4][CH2:3]1.[Cl:17][C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=1)[C:21](Cl)=[O:22]>CCOCC>[ClH:17].[Cl:17][C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=1)[C:21]([N:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]([CH:5]2[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]2)=[N:9]1)=[O:22]

Participants

4

Reactant 2

HCID 69252Benzoyl chloride, 3-chloro-HCID 178480237HCID 178480237, compound

Product 1

HCID 14032531HCID 14032531, compoundYield 67.7%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 3.0 g of 3-(1-methyl-4-piperidinyl)-1H-indazole and 8 ml of 3-chlorobenzoyl chloride was heated at 100° C. for 2 hours. The reaction was allowed to cool, and ether was added. The resultant solid was collected and recrystallized twice from isopropyl alcohol to yield 3.7 g (67.7%) of product, mp 209°-211° C.

Workup

  1. temperatureto cool
  2. customThe resultant solid was collected
  3. customrecrystallized twice from isopropyl alcohol

Sources & evidence

ORD record
ord-b51d5c263cfe4678acea74e2b3c386a7
Source dataset
uspto-grants-1987_06
Patent number
US04670447

Reaction notes

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