Hydrazine hydrate (1:1) → HCID 178419304, compound

HRID 652169Notes

Reaction equation

HRID 652169 reaction equation
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10](=O)[C:11]2[CH:16]=[CH:15][C:14]([Br:17])=[CH:13][C:12]=2F)[CH2:6][CH2:5]1)(=O)C.O.[NH2:21][NH2:22]>>[Br:17][C:14]1[CH:13]=[C:12]2[C:11]([C:10]([CH:7]3[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]3)=[N:21][NH:22]2)=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 14032496HCID 14032496, compound

Product 1

HCID 178419304HCID 178419304, compoundYield 32%

Procedure

A mixture of 9.6 g of 1-acetyl-4-(4-bromo-2-fluorobenzoyl)-piperidine and 50 ml of hydrazine hydrate was stirred in an autoclave at 135°-140° C. for 20 hr. The reaction mixture was quenched with water and the solid was collected. The solid was recrystallized from acetonitrile (charcoal) to yield 2.6 g (32%) of product, mp 163°-165° C.

Workup

  1. customThe reaction mixture was quenched with water
  2. customthe solid was collected
  3. customThe solid was recrystallized from acetonitrile (charcoal)

Sources & evidence

ORD record
ord-ea599e1be22647d58d6bc4062b6cf356
Source dataset
uspto-grants-1987_06
Patent number
US04670447

Reaction notes

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