反应详情

The operation was as in Example 5, starting from 10 g of 1-[2-(1,1-dimethyl-ethyl)-4-quinolyl]-3-[1-(2-phenyl-ethyl)-4-piperidyl]-1-propanone dihydrochloride, 2.2 g of sodium methylate and 0.8 g of sodium borohydride in 250 ml of methanol. 8.4 g of 1-[2-(1,1-dimethyl-ethyl)-4-quinolyl]-3-[1-(2-phenyl-ethyl)-4-piperidyl]-1-propanol dihydrochloride (racemic), which melted at 190° C. were obtained.