HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 1-[2-(1,1-Dimethyl-ethyl)-4-quinolyl]-3-[1-(2-phenyl-ethyl)-4-piperidyl]-1-propanol dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 1-[2-(1,1-Dimethyl-ethyl)-4-quinolyl]-3-[1-(2-phenyl-ethyl)-4-piperidyl]-1-propanone dihydrochloride | HCID 20234129 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-[2-(1,1-Dimethyl-ethyl)-4-quinolyl]-3-[1-(2-phenyl-ethyl)-4-piperidyl]-1-propanol dihydrochloride | HCID 20234124 | 167.3% |
Reaction Steps
The operation was as in Example 5, starting from 10 g of 1-[2-(1,1-dimethyl-ethyl)-4-quinolyl]-3-[1-(2-phenyl-ethyl)-4-piperidyl]-1-propanone dihydrochloride, 2.2 g of sodium methylate and 0.8 g of sodium borohydride in 250 ml of methanol. 8.4 g of 1-[2-(1,1-dimethyl-ethyl)-4-quinolyl]-3-[1-(2-phenyl-ethyl)-4-piperidyl]-1-propanol dihydrochloride (racemic), which melted at 190° C. were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04613607 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-cd969a6e26d34252a9635315ae82f8ec |
| Source note | uspto-grants-1986_09 |