Ammonia → 4-Cyclopropyl-6-methoxy-1,3,5-triazin-2-amine

HRID 652230Notes

Reaction equation

HRID 652230 reaction equation
[NH3:1].[CH:2]1([C:5]2[N:10]=[C:9]([O:11][CH3:12])[N:8]=[C:7](C(Cl)(Cl)Cl)[N:6]=2)[CH2:4][CH2:3]1>O1CCCC1>[NH2:1][C:7]1[N:6]=[C:5]([CH:2]2[CH2:4][CH2:3]2)[N:10]=[C:9]([O:11][CH3:12])[N:8]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 201996182-Cyclopropyl-4-methoxy-6-(trichloromethyl)-1,3,5-triazine

Product 1

HCID 27265914-Cyclopropyl-6-methoxy-1,3,5-triazin-2-amine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
80 °C

Procedure

5 ml of concentrated aqueous ammonia are added to a solution of 1 g of 2-cyclopropyl-4-methoxy-6-trichloromethyl-1,3,5-triazine in 3 ml of tetrahydrofuran; the whole is placed into a bomb tube and heated at 80° C. for 30 minutes. The mixture is cooled and then filtered; the filter residue is dissolved in 30 ml of methylene chloride, and the solution is dried over magnesium sulfate, and concentrated by evaporation. The residue crystallises to leave 0.4 g of white crystals, m.p. 157°-158° C.

Workup

  1. customthe whole is placed into a bomb tube
  2. temperatureThe mixture is cooled
  3. filtrationfiltered
  4. dissolutionthe filter residue is dissolved in 30 ml of methylene chloride
  5. dry with materialthe solution is dried over magnesium sulfate
  6. concentrationconcentrated by evaporation
  7. customThe residue crystallises

Sources & evidence

ORD record
ord-9720cc5151934026a58b09a66c660114
Source dataset
uspto-grants-1987_06
Patent number
US04670559

Reaction notes

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