反应详情

To a slurry of 11.2 g. (0.044 mole) of 3-methylthio-5-phenylindolin-2-one in 500 ml. of tetrahydrofuran was added 100 g. of a commercial Raney nickel/water preparation portionwise over a 2 hr. period. The mixture was filtered through celite and the filtrate was concentrated. A small amount of methylene chloride was added to the residue and the resulting solid was collected by filtration. This solid was recrystallized from toluene to give 6.2 g. (67%) of product as a tan solid, m.p. 214°-15° C.

1. filtrationThe mixture was filtered through celite
2. concentrationthe filtrate was concentrated
3. additionA small amount of methylene chloride was added to the residue
4. filtrationthe resulting solid was collected by filtration
5. customThis solid was recrystallized from toluene
6. customto give 6.2 g