反应详情

温度

0 °C

Dissolve 13.3 g (0.0736 mole) of 4-(4-chlorophenyl)-3- butyn-1-ol in 70 ml pyridine and cool to 0° C. Add 16 g (0.0837 mole) of p-toluenesulfonyl chloride and stir in ice bath for one hour. Store in freezer over night. Add 200 ml diethyl ether and then wash with 3×150 ml 1N hydrochloric acid. The organic layer is then washed with 50 ml saturated aqueous sodium bicarbonate solution and then dried over magnesium sulfate. Evaporate solvent to obtain the title compound.

1. waitStore in freezer over night
2. washwash with 3×150 ml 1N hydrochloric acid
3. washThe organic layer is then washed with 50 ml saturated aqueous sodium bicarbonate solution
4. dry with materialdried over magnesium sulfate