Potassium Hydroxide → Cyclopropyl 4-fluorophenyl ketone

HRID 65230Notes

Reaction equation

HRID 65230 reaction equation
Cl[CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)=[O:6].[OH-].[K+]>O>[CH:4]1([C:5]([C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)=[O:6])[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 197503-(4-Fluorobenzoyl)propyl chloride

Product 1

HCID 69876Cyclopropyl 4-fluorophenyl ketone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Add 20.0 g (0.10 mole) γ-chloro-p-fluorobutyrophenone dropwise to a methanolic KOH solution (prepared from 9.8 g of 86% KOH pellets and 60 ml of methanol). Stir the mixture at room temperature for 40 minutes and pour into 100 ml of water and then extract with 3×30 ml of methylene chloride. Wash the methylene chloride extracts with 3×40 ml of water, dry over magnesium sulfate and evaporate off the solvent to provide the title compound.

Workup

  1. extractionextract with 3×30 ml of methylene chloride
  2. washWash the methylene chloride
  3. dry with materialdry over magnesium sulfate
  4. customevaporate off the solvent

Sources & evidence

ORD record
ord-4cf3b9a24eff49e1960623cdd15230c5
Source dataset
uspto-grants-1986_09
Patent number
US04613609

Reaction notes

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