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Potassium Hydroxide → Cyclopropyl 4-fluorophenyl ketone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 3-(4-Fluorobenzoyl)propyl chloride | HCID 19750 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Cyclopropyl 4-fluorophenyl ketone | HCID 69876 | — |
反応手順
Add 20.0 g (0.10 mole) γ-chloro-p-fluorobutyrophenone dropwise to a methanolic KOH solution (prepared from 9.8 g of 86% KOH pellets and 60 ml of methanol). Stir the mixture at room temperature for 40 minutes and pour into 100 ml of water and then extract with 3×30 ml of methylene chloride. Wash the methylene chloride extracts with 3×40 ml of water, dry over magnesium sulfate and evaporate off the solvent to provide the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04613609 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-4cf3b9a24eff49e1960623cdd15230c5 |
| 出典メモ | uspto-grants-1986_09 |