Hydrochloric Acid → HCID 20197206, compound

HRID 652409Notes

Reaction equation

HRID 652409 reaction equation
[CH3:1][C:2]1[C:3]([CH3:16])=[CH:4][C:5]2[O:11][CH2:10][CH:9]([NH:12][CH3:13])[CH2:8][CH:7](O)[C:6]=2[CH:15]=1.[ClH:17]>CO>[ClH:17].[CH3:1][C:2]1[C:3]([CH3:16])=[CH:4][C:5]2[O:11][CH2:10][CH:9]([NH:12][CH3:13])[CH:8]=[CH:7][C:6]=2[CH:15]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13446255HCID 13446255, compound

Product 1

HCID 20197206HCID 20197206, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10.0 g of 7,8-dimethyl-3-methylamino-2,3,4,5-tetrahydro-1benzoxepin-5-ol were dissolved in 50 ml of methanol saturated with hydrogen chloride, and the solution was heated at reflux for two hours with stirring. Subsequently, the solution was evaporated under vacuum; the residue was dissolved in a 25 percent aqueous ammonia solution, and the alkaline ammonia solution was worked up as described in Example 1. 7.9 g of 7,8-dimethyl-3-methylamino-2,3-dihydro-1-benzoxepine hydrochloride were obtained. Melting point: 216-218 degrees C.

Workup

  1. temperaturethe solution was heated
  2. temperatureat reflux for two hours
  3. customSubsequently, the solution was evaporated under vacuum
  4. dissolutionthe residue was dissolved in a 25 percent aqueous ammonia solution

Sources & evidence

ORD record
ord-cf22fa641aa64379a42dae0b17733d63
Source dataset
uspto-grants-1987_06
Patent number
US04672062

Reaction notes

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