Phthalic Anhydride → HCID 12822524, compound

HRID 652448Notes

Reaction equation

HRID 652448 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=[C:7]2[CH2:13][CH2:14][NH2:15])(=[O:3])[CH3:2].[C:16]1(=O)[O:21][C:19](=[O:20])[C:18]2=[CH:22][CH:23]=[CH:24][CH:25]=[C:17]12.C([O-])(=O)C.[Na+]>C(O)(=O)C>[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=[C:7]2[CH2:13][CH2:14][N:15]1[C:19](=[O:20])[C:18]2[C:17](=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:16]1=[O:21])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 6811Phthalic AnhydrideHCID 20810AcetryptineHCID 517045Sodium Acetate

Product 1

HCID 12822524HCID 12822524, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A suspension of 5-acetyl-1H-indole-3-ethanamine (1.0 g), phthalic anhydride (0.83 g) and sodium acetate (1.0 g) in acetic acid (15 ml) was heated at reflux for 3 h. On cooling the title compound was deposited as an off-white crystalline solid (1.5 g) m.p. 234°-5°.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 3 h

Sources & evidence

ORD record
ord-d50701c0ce8a47deaf2f43b358718739
Source dataset
uspto-grants-1987_06
Patent number
US04672067

Reaction notes

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