反应详情

A solution of 3-iodo-1-tetrahydro-2-pyranyloxy propane (20.43 g, 75.63 mmole), and triphenylphosphine (19.84 g, 75.63 mmole) in 150 ml of dry benzene was refluxed under an atmosphere of nitrogen for 24 hours. The solvent was evaporated in vacuo to give a sticky gum. This was rinsed with acetonitrile (80 ml) when a white solid precipitated out. The solid was filtered and dried over phosphorous pentoxide at 60° C. in vacuo for 20 hours to give 32.8 g of the title B compound.

1. customThe solvent was evaporated in vacuo
2. customto give a sticky gum
3. washThis was rinsed with acetonitrile (80 ml) when a white solid
4. customprecipitated out
5. filtrationThe solid was filtered
6. dry with materialdried over phosphorous pentoxide at 60° C. in vacuo for 20 hours
7. customto give 32.8 g of the title B compound