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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 652484Generated: October 31, 2026

5-Pyrimidinebutanamine → 6-(4-acetyl-3-hydroxy-2-propylphenoxy)-N-[4-(5-pyrimidinyl)-butyl]hexanamide

https://huagongshe.com/reaction/652484

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-PyrimidinebutanamineHCID 13557543—
Reactant6-(4-Acetyl-3-hydroxy-2-propylphenoxy)hexanoic acidHCID 13753873—
Product6-(4-acetyl-3-hydroxy-2-propylphenoxy)-N-[4-(5-pyrimidinyl)-butyl]hexanamideHCID 13912776—

Reaction Steps

6-(4-Acetyl-3-hydroxy-2-propylphenoxy)hexanoic acid was allowed to react with 5-pyrimidine butanamine according to procedure A and the product was purified by crystallization from carbon tetrachloride to give 6-(4-acetyl-3-hydroxy-2-propylphenoxy)-N-[4-(5-pyrimidinyl)-butyl]hexanamide, the title compound mp 87°-89°, in 73% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04672066
Source datasetuspto-grants-1987_06
ORD IDord-6e00bc3a8ebb4b3a8a7b22ae058abadf
Source noteuspto-grants-1987_06