反应详情

A solution of 3.30 g 4-[(4-acetyl-3-hydroxy-2-propylphenoxy)methyl]benzoic acid methyl ester and 48 mL of 1.0 N sodium hydroxide dissolved in 100 mL of methanol was stirred at reflux for 1.25 hour. The solvent was removed in vacuo and the reaction mixture was acidified with 6 N hydrochloric acid. The product was extracted with ethyl acetate and the dried (over magnesium sulfate) extract was concentrated in vacuo to give a solid. Recrystallization from acetonehexane gave 2.613 g, mg 187°-189°, (83% yield) of 4-[(4-acetyl-3-hydroxy-2-propylphenoxy)methyl]benzoic acid, the title compound.

1. temperatureat reflux for 1.25 hour
2. customThe solvent was removed in vacuo
3. extractionThe product was extracted with ethyl acetate
4. dry with materialthe dried (over magnesium sulfate)
5. extractionextract
6. concentrationwas concentrated in vacuo
7. customto give a solid
8. customRecrystallization from acetonehexane