Sodium Hydroxide → HCID 13912815, compound

Participants

Reaction Steps

A solution of 3.30 g 4-[(4-acetyl-3-hydroxy-2-propylphenoxy)methyl]benzoic acid methyl ester and 48 mL of 1.0 N sodium hydroxide dissolved in 100 mL of methanol was stirred at reflux for 1.25 hour. The solvent was removed in vacuo and the reaction mixture was acidified with 6 N hydrochloric acid. The product was extracted with ethyl acetate and the dried (over magnesium sulfate) extract was concentrated in vacuo to give a solid. Recrystallization from acetonehexane gave 2.613 g, mg 187°-189°, (83% yield) of 4-[(4-acetyl-3-hydroxy-2-propylphenoxy)methyl]benzoic acid, the title compound.

Provenance & Evidence