Sodium Hydroxide → 3-[(4-Acetyl-3-hydroxy-2-propylphenoxy)methyl]benzoic acid
Reaction equation
C[O:2][C:3](=[O:25])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18](=[O:20])[CH3:19])=[C:14]([OH:21])[C:13]=2[CH2:22][CH2:23][CH3:24])[CH:5]=1.[OH-].[Na+]>>[C:18]([C:15]1[CH:16]=[CH:17][C:12]([O:11][CH2:10][C:6]2[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=2)[C:3]([OH:25])=[O:2])=[C:13]([CH2:22][CH2:23][CH3:24])[C:14]=1[OH:21])(=[O:20])[CH3:19]Participants
3
Procedure
3-[(4-Acetyl-3-hydroxy-2-propylphenoxy)methyl]benzoic acid methyl ester was allowed to react with 1.0N sodium hydroxide according to the procedure of Example 70 and the product was purified by recrystallization from acetone to give 3-[(4-acetyl-3-hydroxy-2-propylphenoxy)methyl]benzoic acid, the title compound, m.p. 221°-224°, in 92% yield. Analysis Calculated for C19H20O5 : C, 69.50; H, 6.14. Found: C, 69.64; H, 6.35.
Workup
- customthe product was purified by recrystallization from acetone
Sources & evidence
- ORD record
- ord-42ad1c718576426aaec8dd993239965f
- Source dataset
- uspto-grants-1987_06
- Patent number
- US04672066
Reaction notes
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