Potassium Carbonate → HCID 13912826, compound

HRID 652527Notes

Reaction equation

HRID 652527 reaction equation
Br[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:13])[CH3:12])=[C:7]([CH2:14][CH2:15]C)[C:6]=1O.[OH:18][C:19]1[CH:20]=[C:21]([CH:27]=[CH:28][CH:29]=1)[C:22]([O:24][CH2:25][CH3:26])=[O:23].[C:30](=[O:33])([O-])[O-].[K+].[K+]>>[CH2:25]([O:24][C:22](=[O:23])[C:21]1[CH:27]=[CH:28][CH:29]=[C:19]([O:18][CH2:2][CH2:3][O:4][C:5]2[CH:10]=[CH:9][C:8]([C:11](=[O:13])[CH3:12])=[C:30]([OH:33])[C:6]=2[CH2:7][CH2:14][CH3:15])[CH:20]=1)[CH3:26]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 24522Ethyl 3-hydroxybenzoateHCID 20197270HCID 20197270, compound

Product 1

HCID 13912826HCID 13912826, compoundYield 62.3%

Procedure

A mixture of 1.5 g of 1-[4-(2-bromoethoxy)-3-hydroxy-2-propylphenyl]ethanone, 0.83 g of ethyl 3-hydroxybenzoate and 0.95 g of potassium carbonate was allowed to react according to the procedure of Example 79 to give 1.2 g, m.p. 58-60° (62% yield) of 3-[2-(4-acetyl-3-hydroxy-2-propylphenoxy)ethoxy]benzoic acid ethyl ester, the title compound.

Workup

  1. customto react

Sources & evidence

ORD record
ord-75d9e201f25949739ad7010ec010f993
Source dataset
uspto-grants-1987_06
Patent number
US04672066

Reaction notes

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