Ethyl Salicylate → HCID 13912828, compound

HRID 652528Notes

Reaction equation

HRID 652528 reaction equation
Br[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:13])[CH3:12])=[C:7]([CH2:14][CH2:15]C)[C:6]=1O.[OH:18][C:19]1[CH:29]=[CH:28][CH:27]=[CH:26][C:20]=1[C:21]([O:23][CH2:24]C)=[O:22].[C:30](=[O:33])([O-])[O-].[K+].[K+]>>[CH3:24][O:23][C:21](=[O:22])[C:20]1[CH:26]=[CH:27][CH:28]=[CH:29][C:19]=1[O:18][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:13])[CH3:12])=[C:30]([OH:33])[C:6]=1[CH2:7][CH2:14][CH3:15]

Participants

4

Reactant 3

HCID 8365Ethyl SalicylateHCID 11430Potassium CarbonateHCID 20197270HCID 20197270, compound

Product 1

HCID 13912828HCID 13912828, compoundYield 59%

Procedure

A mixture of 1.5 g of 1-[4-(2-bromoethoxy)-3-hydroxy-2-propylphenyl]ethanone, 0.76 g of ethyl 2-hydroxybenzoate and 1.05 g of potassium carbonate was allowed to react according to the procedure of Example 79 to give 1.1 g, m.p. 84°-87°, (59% yield) of 2-[2-(4-acetyl-3-hydroxy-2-propylphenoxy)ethoxy]benzoic acid methyl ester, the title compound.

Workup

  1. customto react

Sources & evidence

ORD record
ord-c35d95c5d18d43d8aac29411ecbd0848
Source dataset
uspto-grants-1987_06
Patent number
US04672066

Reaction notes

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