Methyl Salicylate → HCID 54481319, compound

HRID 652530Notes

Reaction equation

HRID 652530 reaction equation
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12](=[O:14])[CH3:13])=[C:8]([CH2:15][CH2:16]C)[C:7]=1O.[OH:19][C:20]1[CH:29]=[CH:28][CH:27]=[CH:26][C:21]=1[C:22]([O:24][CH3:25])=[O:23].[C:30](=[O:33])([O-])[O-].[K+].[K+]>>[CH3:25][O:24][C:22](=[O:23])[C:21]1[CH:26]=[CH:27][CH:28]=[CH:29][C:20]=1[O:19][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12](=[O:14])[CH3:13])=[C:30]([OH:33])[C:7]=1[CH2:8][CH2:15][CH3:16]

Participants

4

Reactant 3

HCID 4133Methyl SalicylateHCID 11430Potassium CarbonateHCID 20197284HCID 20197284, compound

Product 1

HCID 54481319HCID 54481319, compoundYield 62.5%

Procedure

A mixture of 1.5 g of 1-[4-(3-bromopropoxy)-3-hydroxy-2-propylphenyl]ethanone, 0.73 g of methyl 2-hydroxybenzoate and 1.0 g of potassium carbonate was allowed to react according to Example 79 to give 1.15 g (62% yield) of 2-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]benzoic acid methyl ester, the title compound as an oil.

Workup

  1. customto react

Sources & evidence

ORD record
ord-da34608a2e5246f7943f03b885e4c142
Source dataset
uspto-grants-1987_06
Patent number
US04672066

Reaction notes

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