反应详情

温度

-10 °C

To a -10° C. solution of 8 g (0.064 mole) of 1-[2-(4-aminophenyl)ethyl]-1H-imidazole and 10 mL triethylamine in 200 mL of methylene chloride add 5 mL of methanesulfonyl chloride dropwise. Stir the resulting solution at -10° C. for about 30 minutes then warm to ambient temperature for about 30 minutes. Wash the reaction mixture with water. (2×100 mL). Extract with 10% aqueous sodium hydroxide (2×50 mL). The combined aqueous extracts are neutralized with ammonium chloride then extracted with methylene chloride (2×100 mL) and combined. Remove the solvent in vacuo to provide the title compound, which may be recrystallized from tetrahydrofuran.

1. temperaturethen warm to ambient temperature for about 30 minutes
2. washWash the reaction mixture with water
3. extractionExtract with 10% aqueous sodium hydroxide (2×50 mL)
4. extractionthen extracted with methylene chloride (2×100 mL)
5. customRemove the solvent in vacuo