HCID 13765534, compound → HCID 13765536, compound

HRID 652578Notes

Reaction equation

HRID 652578 reaction equation
[CH3:1][CH:2]([NH:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:3][CH:4](NC(OCC)=O)[NH:5][C:6]([O:8][CH2:9][CH3:10])=[O:7].[H][H]>[Ni].C(O)C>[CH3:1][CH:2]([NH:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:3][CH2:4][NH:5][C:6]([O:8][CH2:9][CH3:10])=[O:7]

Participants

5

Reactant 2

HCID 13765534HCID 13765534, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13765536HCID 13765536, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

10 g of the 3-methyl-1,1,3-tri(ethoxycarbonylamino)propane prepared in Example 3a are hydrogenated at 165° C. and 200 bar of hydrogen in a stirred autoclave with 3 g of Raney nickel and 100 ml of ethanol in the course of 15 hours. Complete converion gives 1-methyl-1,3-di(ethoxycarbonylamino)propane with a selectivity of 96%.

Workup

  1. customare hydrogenated at 165° C.
  2. customin the course of 15 hours

Sources & evidence

ORD record
ord-c63bdcc7717f412eb016703e1eb12519
Source dataset
uspto-grants-1987_06
Patent number
US04672137

Reaction notes

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