Hydrazine → HCID 13914722, compound

HRID 652585Notes

Reaction equation

HRID 652585 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([O:18][CH3:19])[C:5]([O:16][CH3:17])=[C:6]2[C:11]=1[N:10]=[C:9]([O:12][CH3:13])[N:8]=[C:7]2OC.[NH2:20][NH2:21]>CO>[Cl:1][C:2]1[CH:3]=[C:4]([O:18][CH3:19])[C:5]([O:16][CH3:17])=[C:6]2[C:11]=1[N:10]=[C:9]([O:12][CH3:13])[N:8]=[C:7]2[NH:20][NH2:21]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 13914721HCID 13914721, compound

Product 1

HCID 13914722HCID 13914722, compoundYield 66.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 8-chloro-2,4,5,6-tetramethoxyquinazoline (1.0 g, 0.0035 moles), anhydrous hydrazine (5 ml, 0.16 moles) and methanol (50 ml) was stirred at reflux for 0.5 hours. The solvent was removed in vacuo and the residue was recrystallized from methanol. The resulting crystals were washed with methanol (20 ml) and dried under vacuum at 50° C. to afford the product (0.665 g), mp 166°-168° C.

Workup

  1. temperatureat reflux for 0.5 hours
  2. customThe solvent was removed in vacuo
  3. customthe residue was recrystallized from methanol
  4. washThe resulting crystals were washed with methanol (20 ml)
  5. customdried under vacuum at 50° C.

Sources & evidence

ORD record
ord-076c54ba505347bab5f8cf3df46e54cc
Source dataset
uspto-grants-1987_06
Patent number
US04672116

Reaction notes

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