Ammonia → HCID 13914730, compound

HRID 652589Notes

Reaction equation

HRID 652589 reaction equation
[CH3:1][O:2][C:3]1[N:12]=[C:11](OC)[C:10]2[C:5](=[C:6]([Cl:19])[CH:7]=[C:8]([O:17][CH3:18])[C:9]=2[O:15][CH3:16])[N:4]=1.[NH3:20]>>[NH2:20][C:11]1[C:10]2[C:5](=[C:6]([Cl:19])[CH:7]=[C:8]([O:17][CH3:18])[C:9]=2[O:15][CH3:16])[N:4]=[C:3]([O:2][CH3:1])[N:12]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 13914721HCID 13914721, compound

Product 1

HCID 13914730HCID 13914730, compound

Procedure

A mixture of 2,4,5,6-tetramethoxy-8-chloroquinazoline (2.1 g, 0.0073 moles) and saturated methanolic ammonia (60 ml) was warmed to 80° C. for 16 hours in a teflon lined acid digestion bomb. The crude reaction mixture was filtered, and the resulting solid was recrystallized twice from N,N-dimethylformamide, washed three times with methanol and dried under vacuum at 60° C. to afford the product (1.08 g), mp 203°-204° C.

Workup

  1. customThe crude reaction mixture
  2. filtrationwas filtered
  3. customthe resulting solid was recrystallized twice from N,N-dimethylformamide
  4. washwashed three times with methanol
  5. customdried under vacuum at 60° C.

Sources & evidence

ORD record
ord-a51ac3030d124abfaac7d3a903b153ba
Source dataset
uspto-grants-1987_06
Patent number
US04672116

Reaction notes

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