Ammonia → HCID 13914730, compound

Participants

Reaction Steps

A mixture of 2,4,5,6-tetramethoxy-8-chloroquinazoline (2.1 g, 0.0073 moles) and saturated methanolic ammonia (60 ml) was warmed to 80° C. for 16 hours in a teflon lined acid digestion bomb. The crude reaction mixture was filtered, and the resulting solid was recrystallized twice from N,N-dimethylformamide, washed three times with methanol and dried under vacuum at 60° C. to afford the product (1.08 g), mp 203°-204° C.

Provenance & Evidence