Hydrogen Peroxide → HCID 53821939, compound

HRID 652733Notes

Reaction equation

HRID 652733 reaction equation
[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([N+:12]([O-:14])=[O:13])=[CH:9][CH:10]=2)[CH:5]=[N:4][CH:3]=1.[OH:15]O>C(O)(=O)C>[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([N+:12]([O-:14])=[O:13])=[CH:9][CH:10]=2)[CH:5]=[N+:4]([O-:15])[CH:3]=1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 20196470HCID 20196470, compound

Product 1

HCID 53821939HCID 53821939, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 4-methyl-7-nitroisoquinoline (400 mg), and 30% hydrogen peroxide (0.65 ml) in acetic acid (2 ml) was refluxed for 3.5 hours. After removal of the solvent, the residue in ether (50 ml) was stirred to give yellow powder. The powder was collected and washed with ether and dried to give 4-methyl-7-nitroisoquinoline N-oxide (360 mg).

Workup

  1. customAfter removal of the solvent
  2. customto give yellow powder
  3. customThe powder was collected
  4. washwashed with ether
  5. customdried

Sources & evidence

ORD record
ord-6e15e167a7fb424cbff0d7ed0244b707
Source dataset
uspto-grants-1987_06
Patent number
US04673676

Reaction notes

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