HCID 13606796, compound → HCID 13606797, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of ethyl 7-methyl-10-nitro-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate (260 mg) in a mixture of acetic acid (6 ml) and 36% hydrochloric acid (3 ml) was refluxed for 50 minutes. The mixture was cooled to 0° C. to give yellow solid. The yellow solid was collected and dried to give 7-methyl-10-nitro-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylic acid (180 mg).

Provenance & Evidence