HCID 13606796, compound → HCID 13606797, compound

HRID 652735Notes

Reaction equation

HRID 652735 reaction equation
[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([N+:12]([O-:14])=[O:13])=[CH:9][CH:10]=2)[C:5]2=[N:15][CH:16]=[C:17]([C:20]([O:22]CC)=[O:21])[C:18](=[O:19])[N:4]2[CH:3]=1>C(O)(=O)C.Cl>[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([N+:12]([O-:14])=[O:13])=[CH:9][CH:10]=2)[C:5]2=[N:15][CH:16]=[C:17]([C:20]([OH:22])=[O:21])[C:18](=[O:19])[N:4]2[CH:3]=1

Participants

4

Reactant 1

HCID 13606796HCID 13606796, compound

Product 1

HCID 13606797HCID 13606797, compoundYield 75.7%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 313Hydrochloric AcidSolvent

Conditions

Temperature
0 °C

Procedure

A suspension of ethyl 7-methyl-10-nitro-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate (260 mg) in a mixture of acetic acid (6 ml) and 36% hydrochloric acid (3 ml) was refluxed for 50 minutes. The mixture was cooled to 0° C. to give yellow solid. The yellow solid was collected and dried to give 7-methyl-10-nitro-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylic acid (180 mg).

Workup

  1. temperaturewas refluxed for 50 minutes
  2. customto give yellow solid
  3. customThe yellow solid was collected
  4. customdried

Sources & evidence

ORD record
ord-7547f8f28fbf45b6bd1896884d4ea076
Source dataset
uspto-grants-1987_06
Patent number
US04673676

Reaction notes

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