Sodium Bicarbonate → HCID 13606804, compound

Participants

Reaction Steps

A solution of 7-methyl-10-nitro-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylic acid (300 mg) in N,N-dimethylformamide (40 ml) was added to an aqueous sodium bicarbonate solution (60 ml). After being stirred for 1 hour, the mixture was allowed to stand in a refrigerator and the resultant precipitate was collected by filtration. To the solid was added aqueous methanol, stirred at room temperature, and collected by suction to give sodium 7-methyl-10-nitro-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate (0.29 g).

Provenance & Evidence