Sodium Bicarbonate → HCID 13606804, compound

HRID 652740Notes

Reaction equation

HRID 652740 reaction equation
[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([N+:12]([O-:14])=[O:13])=[CH:9][CH:10]=2)[C:5]2=[N:15][CH:16]=[C:17]([C:20]([OH:22])=[O:21])[C:18](=[O:19])[N:4]2[CH:3]=1.C(=O)(O)[O-].[Na+:27]>CN(C)C=O>[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([N+:12]([O-:14])=[O:13])=[CH:9][CH:10]=2)[C:5]2=[N:15][CH:16]=[C:17]([C:20]([O-:22])=[O:21])[C:18](=[O:19])[N:4]2[CH:3]=1.[Na+:27]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 13606797HCID 13606797, compound

Product 1

HCID 13606804HCID 13606804, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 7-methyl-10-nitro-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylic acid (300 mg) in N,N-dimethylformamide (40 ml) was added to an aqueous sodium bicarbonate solution (60 ml). After being stirred for 1 hour, the mixture was allowed to stand in a refrigerator and the resultant precipitate was collected by filtration. To the solid was added aqueous methanol, stirred at room temperature, and collected by suction to give sodium 7-methyl-10-nitro-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate (0.29 g).

Workup

  1. filtrationthe resultant precipitate was collected by filtration
  2. additionTo the solid was added aqueous methanol
  3. stirringstirred at room temperature
  4. customcollected by suction

Sources & evidence

ORD record
ord-2bec7cac51854c6e8df882a3a9dd78cb
Source dataset
uspto-grants-1987_06
Patent number
US04673676

Reaction notes

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