HCID 13606811, compound → HCID 13606812, compound

HRID 652744Notes

Reaction equation

HRID 652744 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]1[C:17](=[O:18])[C:16]([C:19]([O:21]CC)=[O:20])=[CH:15][N:14]=[C:9]12)([O-:3])=[O:2]>C(O)(=O)C.Cl.O>[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]1[C:17](=[O:18])[C:16]([C:19]([OH:21])=[O:20])=[CH:15][N:14]=[C:9]12)([O-:3])=[O:2]

Participants

5

Reactant 1

HCID 13606811HCID 13606811, compound

Product 1

HCID 13606812HCID 13606812, compoundYield 87.9%

Reagents, catalysts & solvents 3

HCID 176Acetic AcidSolventHCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

A suspension of ethyl 8-nitro-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate (400 mg) in a mixture of acetic acid (20 ml) and 36% hydrochloric acid (4 ml) was heated at 80° C. for 5 hours. The mixture was cooled and diluted with water. The precipitated solid obtained was collected and dried to give 8-nitro-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylic acid (320 mg).

Workup

  1. temperatureThe mixture was cooled
  2. customThe precipitated solid obtained
  3. customwas collected
  4. customdried

Sources & evidence

ORD record
ord-66b92bf65bfa41df8f5876dec7a9bc31
Source dataset
uspto-grants-1987_06
Patent number
US04673676

Reaction notes

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