HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Methoxy-3-isopropyl-5-sulphamoyl-6-methylbenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Methoxy-3-isopropyl-5-sulphamoyl-6-methylbenzoic acid | HCID 20196838 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-Methoxy-3-isopropyl-5-sulphamoyl-6-methylbenzoyl chloride | HCID 20196820 | — |
Reaction Steps
72 g of 2-methoxy-3-isopropyl-5-sulphamoyl-6-methylbenzoic acid (0.25 mole), 250 ml of chloroform, 23 ml of thionyl chloride and 3 drops of dimethylformamide are placed in a 1 liter flask fitted with an agitator and a condenser. The mixture is heated to reflux for 1.5 hours, then 18 ml of thionyl chloride is added and the reflux is continued for 1.5 hours. The solids dissolve completely.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04673686 |
| Source dataset | uspto-grants-1987_06 |
| ORD ID | ord-d2d56191e7bf4e59bfa653ea03ba0440 |
| Source note | uspto-grants-1987_06 |