Hydroxyamine hydrochloride → HCID 86741598, compound

HRID 652840Notes

Reaction equation

HRID 652840 reaction equation
[Cl:1][C:2]1[C:12]([Cl:13])=[C:11]([C:14](=O)[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])[CH:10]=[CH:9][C:3]=1[O:4][CH2:5][C:6]([OH:8])=[O:7].Cl.[NH2:24][OH:25]>N1C=CC=CC=1>[Cl:1][C:2]1[C:12]([Cl:13])=[C:11]([C:14](=[N:24][OH:25])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])[CH:10]=[CH:9][C:3]=1[O:4][CH2:5][C:6]([OH:8])=[O:7]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 14012549HCID 14012549, compound

Product 1

HCID 86741598HCID 86741598, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 1.0 g of 2.3-dichloro-4-(2-fluorobenzoyl)phenoxyacetic acid and 1 g of hydroxylamine hydrochloride in 10 ml of pyridine is refluxed for 2 hours. Thereafter, the solvent is evaporated in vacuo and the residue is stirred for 16 hours with 5% hydrochloric acid. The product is filtered off and the collected solid is recrystallized from aqueous ethyl alcohol to give the product 2,3-dichloro-4-(2-fluorobenzohydroximoyl)phenoxyacetic acid having a melting point of 91° to 96° C.

Workup

  1. temperatureis refluxed for 2 hours
  2. customThereafter, the solvent is evaporated in vacuo
  3. filtrationThe product is filtered off
  4. customthe collected solid is recrystallized from aqueous ethyl alcohol

Sources & evidence

ORD record
ord-3033415fba8f4529b9ed126d1132733f
Source dataset
uspto-grants-1987_06
Patent number
US04673746

Reaction notes

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