Hydrochloric Acid → HCID 13015750, compound

HRID 652848Notes

Reaction equation

HRID 652848 reaction equation
C([O:3][C:4](=[O:24])[CH2:5][O:6][C:7]1[CH:22]=[CH:21][C:10]2[C:11]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)=[N:12][O:13][C:9]=2[C:8]=1[Cl:23])C.Cl>O>[Cl:23][C:8]1[C:9]2[O:13][N:12]=[C:11]([C:14]3[CH:15]=[CH:16][C:17]([Cl:20])=[CH:18][CH:19]=3)[C:10]=2[CH:21]=[CH:22][C:7]=1[O:6][CH2:5][C:4]([OH:24])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14012482HCID 14012482, compound

Product 1

HCID 13015750HCID 13015750, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 25 g of ethyl{[7-chloro-3-(4-chlorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetate, Example 14, and 20 ml of 50% The hot mixture is diluted with 300 ml of water and then acidified with concentrated hydrochloric acid. The acidified mixture is stirred for 30 minutes and then filtered and the filter cake is recrystallized from a dimethylformamide-ethylacetate mixture to yield the product {[7-chloro-3-(4-chlorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid having a melting point of 254° to 257° C.

Workup

  1. filtrationfiltered
  2. customthe filter cake is recrystallized from a dimethylformamide-ethylacetate mixture

Sources & evidence

ORD record
ord-a822822ce99f4418830425b5464b96b8
Source dataset
uspto-grants-1987_06
Patent number
US04673746

Reaction notes

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