Hydroxyamine hydrochloride → HCID 136393680, compound

HRID 652871Notes

Reaction equation

HRID 652871 reaction equation
[Cl:1][C:2]1[C:17]([Cl:18])=[C:16]([OH:19])[CH:15]=[CH:14][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:7]=1[CH3:13])=O.Cl.[NH2:21][OH:22]>N1C=CC=CC=1>[Cl:1][C:2]1[C:17]([Cl:18])=[C:16]([OH:19])[CH:15]=[CH:14][C:3]=1[C:4](=[N:21][OH:22])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:7]=1[CH3:13]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 201505412,3-Dichloro-4-hydroxy-2',3'-dimethylbenzophenone

Product 1

HCID 136393680HCID 136393680, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 31 g of 2,3-dichloro-4-hydroxy-2',3'-dimethylbenzophenone and 30.5 g of hydroxylamine hydrochloride in 250 ml of pyridine is refluxed for about one week. The pyridine is evaporated in vacuo and the residue is partitioned between ethyl acetate and 5% HCl. The ethylacetate extract is washed, dried over Na2SO4 and evaporated. Trituration with hexane gives 2,3-dichloro-4-hydroxy-2',3'-dimethylbenzophenone oxime.

Workup

  1. temperatureis refluxed for about one week
  2. customThe pyridine is evaporated in vacuo
  3. customthe residue is partitioned between ethyl acetate and 5% HCl
  4. extractionThe ethylacetate extract
  5. washis washed
  6. dry with materialdried over Na2SO4
  7. customevaporated

Sources & evidence

ORD record
ord-582e3a563db447eca18692973418e397
Source dataset
uspto-grants-1987_06
Patent number
US04673746

Reaction notes

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