HCID 13015692, compound → HCID 135589642, compound

HRID 652875Notes

Reaction equation

HRID 652875 reaction equation
[Cl:1][C:2]1[C:10]2[O:9][N:8]=[C:7]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=3)[C:6]=2[CH:5]=[CH:4][C:3]=1[O:17]C>Br>[Cl:1][C:2]1[C:10]2[O:9][N:8]=[C:7]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=3)[C:6]=2[CH:5]=[CH:4][C:3]=1[OH:17]

Participants

3

Reactant 1

HCID 13015692HCID 13015692, compound

Product 1

HCID 135589642HCID 135589642, compound

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

7-chloro-6-methoxy-3-(2-pyridyl)-1,2-benzisoxazole (24.4 g) is refluxed for 1.5 hours in 450 ml of 48% HBr. The precipitated hydrobromide salt is filtered off, washed with ether and neutralized with 10% NaHCO3 solution. The free base is filtered off and dried, giving 7-chloro-6-hydroxy-3-(2-pyridyl)-1,2-benzisoxazole, mp 209°-211° C.

Workup

  1. filtrationThe precipitated hydrobromide salt is filtered off
  2. washwashed with ether and neutralized with 10% NaHCO3 solution
  3. filtrationThe free base is filtered off
  4. customdried

Sources & evidence

ORD record
ord-95600d5953424c2b90b85a7c7bb0c98f
Source dataset
uspto-grants-1987_06
Patent number
US04673746

Reaction notes

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