反应详情

A solution of 3.6 g of ethyl-2-{[3-(4-chlorophenyl)-1,2-benzisoxazol-6-yl]oxy}butyrate, 30 ml of 15% sodium hydroxide solution and 30 ml of methanol, is stirred under reflux for 3 hr. The methanol is evaporated and the solution is poured into dilute hydrochloric acid/ice affording a flocculant precipitate. The precipitate is collected, dried in vacuo and recrystallized from toluene to afford 2-{[3-(4-chlorophenyl)-1,2-benzisoxazol-6-yl]oxy}butyric acid, mp 144° C.

1. temperatureunder reflux for 3 hr
2. customThe methanol is evaporated
3. additionthe solution is poured into dilute hydrochloric acid/ice affording a flocculant precipitate
4. customThe precipitate is collected
5. customdried in vacuo
6. customrecrystallized from toluene